FND_GLOBAL.APPS_INITIALIZE is used for initializing the session before calling any public or private API’s in Oracle Ebusiness suite. Its not required for all the API’s but its recommended that you set this profile before making any calls to either private or public API. 


Listed below is a sample call to FND_GLOBAL.APPS_INITIALIZE function


fnd_global.APPS_INITIALIZE(user_id=>l_user_id, 
                           resp_id=>l_resp_id, 
                           resp_appl_id=>l_resp_appl_id);


l_user_id is the fnd user ID which will be utilized during the call. 
l_resp_id is the responsibility ID 
l_resp_appl_id is the responsibility application ID. 
You can use either sysadmin or use some user who has all the above listed responsibilities.


For SYSADMIN, utilize the following query to get the respective values


select fnd.user_id , 
       fresp.responsibility_id, 
       fresp.application_id 
from   fnd_user fnd 
,      fnd_responsibility_tl fresp 
where  fnd.user_name = ‘SYSADMIN’ 
and    fresp.responsibility_name = ‘Order Management Super User’;


Another option is Help > Diagnostics > Examine and get the values from $profile session values.